Abstract
Nutritional-related diseases such as obesity, hyperlipidemia, type 2 diabetes, cardiovascular disorders, hypertension or cancer are increasingly prevalent in industrialized countries. Dietary lipids have been found to play a significant role in the prevention and improvement of the management of several of these chronic diseases. Closely to 10% of the intake of total dietary lipids correspond to phospholipids (PLs), which have been recognized as important contributors to their beneficial effects in human health. Bioactive PLs have essential roles as signaling and regulatory molecules, being involved in major cell functions such as cell growth, death, senescence, adhesion, migration or cell integrity. The analysis of the mechanisms of how PLs are involved in these varied cell functions is necessary for understanding and profiting from bioactive PLs action. This review explores the genomic bases of the physiological functions and molecular actions of bioactive PLs, and their effect in the development of chronic diseases.
Keywords: Dietary phospholipids, chronic diseases, nutrigenomics, phosphatidylcholine, phosphatidylethanolamine, phosphatidilserine, phosphatidylinositol, obesity, hyperlipidemia, type 2 diabetes, cardiovascular disorders, hypertension, cancer, Dietary lipids, phospholipids, glycerol, sphingosine, fatty acids, lipoprotein, platelet, acetyl-CoA, tricarboxylic acid, Lecithin, plasma
Current Nutrition & Food Science
Title: Beneficial Effects of Bioactive Phospholipids: Genomic Bases
Volume: 7 Issue: 3
Author(s): Isabel Espinosa-Salinas, Arantxa Rodriguez-Casado, Susana Molina, Agustin Rodriguez-Gonzalez, Jose M. Ordovas and Ana Ramirez de Molina
Affiliation:
Keywords: Dietary phospholipids, chronic diseases, nutrigenomics, phosphatidylcholine, phosphatidylethanolamine, phosphatidilserine, phosphatidylinositol, obesity, hyperlipidemia, type 2 diabetes, cardiovascular disorders, hypertension, cancer, Dietary lipids, phospholipids, glycerol, sphingosine, fatty acids, lipoprotein, platelet, acetyl-CoA, tricarboxylic acid, Lecithin, plasma
Abstract: Nutritional-related diseases such as obesity, hyperlipidemia, type 2 diabetes, cardiovascular disorders, hypertension or cancer are increasingly prevalent in industrialized countries. Dietary lipids have been found to play a significant role in the prevention and improvement of the management of several of these chronic diseases. Closely to 10% of the intake of total dietary lipids correspond to phospholipids (PLs), which have been recognized as important contributors to their beneficial effects in human health. Bioactive PLs have essential roles as signaling and regulatory molecules, being involved in major cell functions such as cell growth, death, senescence, adhesion, migration or cell integrity. The analysis of the mechanisms of how PLs are involved in these varied cell functions is necessary for understanding and profiting from bioactive PLs action. This review explores the genomic bases of the physiological functions and molecular actions of bioactive PLs, and their effect in the development of chronic diseases.
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Cite this article as:
Espinosa-Salinas Isabel, Rodriguez-Casado Arantxa, Molina Susana, Rodriguez-Gonzalez Agustin, M. Ordovas Jose and Ramirez de Molina Ana, Beneficial Effects of Bioactive Phospholipids: Genomic Bases, Current Nutrition & Food Science 2011; 7 (3) . https://dx.doi.org/10.2174/157340111797264859
DOI https://dx.doi.org/10.2174/157340111797264859 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
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