Abstract
The morbidity and mortality after solid organ transplantation leads to poor outcomes in the long-term graft survival. There are many sources increasing bad outcomes within the post-transplant period reducing the quality of recipient´s life, such as rejection episodes, opportunistic infections as well as immunosuppression related morbidity. A complete understanding on the immune system responses against the allo-graft remains unknown. Recently, some pro-inflammatory cytokines, such as IFN-γ and IL-17, as well as IL-2, have been proposed as surrogate biomarkers able to predict the appearance of clinical event episodes. In this review we summarize the latest findings regarding the immune function monitoring in solid organ transplantation as well as the most common techniques (ELISPOT, ELISA and Flow Cytometry) that have been widely used across different clinical laboratories.
Keywords: Immune function monitoring, predictive biomarkers, acute rejection, opportunistic infection, cytokine.
Current Protein & Peptide Science
Title:Cytokine Expression Profile as Predictive Surrogate Biomarkers for Clinical Events in the Field of Solid Organ Transplantation
Volume: 18 Issue: 3
Author(s): Francisco Boix, Anna Mrowiec and Manuel Muro
Affiliation:
Keywords: Immune function monitoring, predictive biomarkers, acute rejection, opportunistic infection, cytokine.
Abstract: The morbidity and mortality after solid organ transplantation leads to poor outcomes in the long-term graft survival. There are many sources increasing bad outcomes within the post-transplant period reducing the quality of recipient´s life, such as rejection episodes, opportunistic infections as well as immunosuppression related morbidity. A complete understanding on the immune system responses against the allo-graft remains unknown. Recently, some pro-inflammatory cytokines, such as IFN-γ and IL-17, as well as IL-2, have been proposed as surrogate biomarkers able to predict the appearance of clinical event episodes. In this review we summarize the latest findings regarding the immune function monitoring in solid organ transplantation as well as the most common techniques (ELISPOT, ELISA and Flow Cytometry) that have been widely used across different clinical laboratories.
Export Options
About this article
Cite this article as:
Boix Francisco, Mrowiec Anna and Muro Manuel, Cytokine Expression Profile as Predictive Surrogate Biomarkers for Clinical Events in the Field of Solid Organ Transplantation, Current Protein & Peptide Science 2017; 18 (3) . https://dx.doi.org/10.2174/1389203717666160902130001
DOI https://dx.doi.org/10.2174/1389203717666160902130001 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chemokines and their Receptors in Gut Homeostasis and Disease
Current Immunology Reviews (Discontinued) Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease
Current Medicinal Chemistry Design of Bioartificial Pancreas with Functional Micro/Nano-Based Encapsulation of Islets
Current Pharmaceutical Biotechnology Current Status of Vitamin D Signaling and Its Therapeutic Applications
Current Topics in Medicinal Chemistry The Expression of Endotoxic Activity in the Limulus Test as Compared to Cytokine Production in Immune Cells
Current Medicinal Chemistry Gender And Susceptibility To Sepsis Following Trauma
Endocrine, Metabolic & Immune Disorders - Drug Targets Computational Methods for Remote Homolog Identification
Current Protein & Peptide Science Immunophilin Chaperones in Steroid Receptor Signalling
Current Topics in Medicinal Chemistry The Role of Organic Transporters in Pharmacokinetics and Nephrotoxicity of Newer Antiviral Therapies for HIV and Hepatitis C
Current Drug Metabolism Cell Immunity in Inflammatory Vasculitis
Current Immunology Reviews (Discontinued) Transendothelial Migration of Monocytes: The Underlying Molecular Mechanisms and Consequences of HIV-1 Infection
Current HIV Research Biologics for the Treatment of Juvenile Idiopathic Arthritis
Current Medicinal Chemistry Cyanobacterial Polyhydroxyalkanoate Production: Status Quo and Quo Vadis?
Current Biotechnology Periodontal Film: A Potential Treatment Strategy for Periodontitis
Drug Delivery Letters Younger for Longer: Insulin Signalling, Immunity and Ageing
Current Aging Science NOX3-Targeted Therapies for Inner Ear Pathologies
Current Pharmaceutical Design A Review of Fish Lectins
Current Protein & Peptide Science Carrier Mediated Systemic Delivery of Protein and Peptide Therapeutics
Current Pharmaceutical Design Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications
Current Genomics Study on Transcriptional Responses and Identification of Ribosomal Protein Genes for Potential Resistance against Brown Planthopper and Gall Midge Pests in Rice
Current Genomics